The System agnostic reference article from the English Wikipedia on 24-Apr-2004
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System agnostic

Helping orphans the way you would do it
System agnostic is a term which refers to the notion that a particular computing technology (or person, in the case of system administrators and programmers) does not depend entirely on the ideology of another, as in "OS agnostic" or "editor agnostic."

The term system agnostic is also used in role-playing games to describe scenarios and supplements (or persons, in the case of players and gamemasters) which can be used within a variety of gaming systems and settings.