The Sigma factor reference article from the English Wikipedia on 24-Apr-2004 (provided by Fixed Reference: snapshots of Wikipedia from wikipedia.org)

Sigma factor

Sigma factor (σ factor) is an initiation factor that binds to RNA polymerase and promotes attachment to promoter sites on DNA.

Structure

Sigma factor has four main regions:

N----------C

• 1  2  3  4
  
  

  Region 1 regulates interaction with DNA.
• Region 2 binds RNAP and binds to the -10 promoter site.
• Region 4 binds to the -35 promoter site.

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