Recessive gene
In genetics, the term "recessive gene" refers to an allele that causes a phenotype that is only seen in a homozygous genotype. However, the term "recessive gene" is sloppy language use. Properly, it is the phenotype (or trait) which is recessive, not the gene.Dominance/recessiveness refers to phenotype, not genotype. An example to prove the point is sickle cell anemia. The sickle cell genotype is caused by a single base pair change in the beta-globin gene: normal=GAG (glu), sickle=GTG (val). There are several phenotypes associated with the sickle genotype:
- anemia (a recessive trait),
- blood cell sickling (partially dominant),
- altered beta-globin electrophoretic mobility (codominant), and
- resistance to malaria (dominant).
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