Mosaic (genetics)

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In medicine (genetics), a mosaic or mosaicism denotes the presence of two populations of cells in one patient, where usually one of the two is affected by a genetic disorder.

Although most forms of trisomy are due to problems in meiosis and affect all cells of the zygote, there are cases where the trisomy only occurs in a selection of the cells. Generally this leads to a milder phenotype than in non-mosaic patients with the same disorder.

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