The Leptin reference article from the English Wikipedia on 24-Apr-2004 (provided by Fixed Reference: snapshots of Wikipedia from wikipedia.org)

Leptin

Leptin is a hormone secreted by full fat cells. The hypothalamus detects its presence and indicates that fat storage is plentiful. Leptin works by inhibiting the actions of neuropeptide Y, which is the most potent appetite stimulant yet discovered.

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