The Gastrointestinal stromal tumor reference article from the English Wikipedia on 24-Apr-2004 (provided by Fixed Reference: snapshots of Wikipedia from wikipedia.org)

Gastrointestinal stromal tumor

In medical oncology, gastrointestinal stromal cell tumors (GIST) are tumors arising from stromal cell tissue in the gastrointestinal tract. A GIST is a form of sarcoma.

Pathophysiology

To be filled in

The c-kit molecule (CD117) is a tyrosine kinase, which makes GIST tumors amenable to therapy with imatinib (see below).

Recent developments

The new drug imatinib (Glivec^®, Gleevec^®) specifically inhibits a number of tyrosine kinases, including c-kit. Its other therapeutic targets include chronic myelogenous leukemia (CML).

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