Brainiac
- Brainiac is a fictional supervillain in DC Comics, most often appearing as an opponent of Superman.
- Brainiac was an American indie rock band.
- is a television programme showing in the UK on Sky One (and repeated on Sky One Mix).
- Brainiac was a later, lower-priced, reduced-functionality version of the Geniac, a 1950s toy, billed as a "computer" (but actually no more than a rotary-switch construction set).